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Product details

名称

Recombinant Human CXCL7/NAP-2 Protein

别名

重组人CXCL7/NAP-2蛋白 | 重组人趋化因子(C-X-C基序)7蛋白 | 重组人中性粒细胞活化蛋白2

英文别名

货号

rp181578-10μg

包装规格

10μg

级别

无载体

浓度

≥90%(SDS-PAGE)

生化机理

Neutrophil Activating Peptide 2 (NAP-2), Connective Tissue Activating Protein III (CTAP-III) and beta -thrombogulin ( beta -TG), are proteolytically processed carboxyl-terminal fragments of platelet basic protein (PBP) which is found in the alpha-granules of human platelets. NAP-2 is a member of the CXC chemokines. Similar to other ELR domain containing CXC chemokines such as IL-8 and the GRO proteins, NAP-2 has been shown to bind CXCR2 and to chemoattract and activate neutrophils. Although CTAP-III, beta -TG and PBP represent amino-terminal extended variants of NAP-2 and possess the same CXC chemokine domains, these proteins do not exhibit NAP-2 activity. It has been shown that the additional amino-terminal residues of CTAP-III masks the critical ELR receptor binding domain that is exposed on NAP-2 and may account for lack of NAP-2 activity. Post-translational: Proteolytic removal of residues 1-9 produces the active peptide connective tissue-activating peptide III (CTAP-III) (low-affinity platelet factor IV (LA-PF4)).Proteolytic removal of residues 1-13 produces the active peptide beta-thromboglobulin, which is released from platelets along with platelet factor 4 and platelet-derived growth factor. NAP-2(1-66) is produced by proteolytical processing, probably after secretion by leukocytes other than neutrophils. NAP-273 and NAP-274 seem not be produced by proteolytical processing of secreted precursors but are released in an active form from platelets.

生物活性

Testing in progress

来源

重组表达

预测分子量

7.6 kDa

蛋白标签

No tag

SDS-PAGE

10.2 kDa, under reducing conditions; 10.7 & 11.2 kDa, under non-reducing conditions.

表达系统

E. coli Accession #: P02775 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

59-128 aa

序列

AELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDESAD

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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