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Product details

名称

Recombinant Human CD46 Protein

别名

重组人CD46蛋白 | 重组人 CD46 蛋白

英文别名

货号

rp181587-10μg

包装规格

10μg

级别

无动物源

浓度

≥95%(SDS-PAGE)

产品介绍

CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. Human CD46 shares 5% amino acid sequence identity with mouse and rat CD46. The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic-uremic syndrome (aHUS), a disease characterized by uncontrolled complement activation. CD46 is implicated in the development and/or progression of selected cancer types.

生物活性

Immobilized Recombinant Human CD46 Protein (rp181587) at 1.0 μg/mL can bind Recombinant CD46 Antibody (Ab094952) with the EC50 of 5.7 ng/mL.

来源

重组表达

预测分子量

34.0 kDa

蛋白标签

C-His

SDS-PAGE

37.0-65.0 kDa, under reducing conditions; 42.0-63.0 kDa, under non-reducing conditions

表达系统

HEK293 Accession #: P15529 | HEK293

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

1-328 aa

序列

MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGPRPTYKPPVSNYHHHHHHHHHH

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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