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Product details
名称
Recombinant Human CD155/PVR Protein
别名
重组人CD155/PVR蛋白 | 重组人脊髓灰质炎病毒受体蛋白
英文别名
CD155 | CD155 antigen | FLJ25946 | HVED | mE4 | NECL 5 | Necl-5 | Necl5 | Nectin like 5 | Nectin like protein 5 | Nectin-like protein 5 | Ortholog of mouse Tage4 | Poliovirus receptor | TAGE4 | Tage 4 | PVR | PVR_HUMAN | PVS | Taa1
货号
rp181610-10μg
包装规格
10μg
级别
无动物源
浓度
≥95%(SDS-PAGE)
生化机理
介导 NK 细胞粘附并触发 NK 细胞效应功能。与两种不同的 NK 细胞受体结合:CD96 和 CD226。这些相互作用聚集在细胞-细胞接触部位,导致 NK 细胞与靶细胞之间形成成熟的免疫突触。这可能会触发粘附并分泌溶解颗粒和 IFN-γ,激活活化的 NK 细胞的细胞毒性。还可能促进 NK 细胞与靶细胞之间的模块交换,以及 PVR 向 NK 细胞的转移。这种转移在一些表达大量 PVR 的肿瘤细胞中更为重要,并可能引发自相残杀的 NK 细胞活化,为肿瘤提供一种免疫逃避机制。在介导肿瘤细胞侵袭和迁移方面发挥作用。作为脊髓灰质炎病毒附着于靶细胞的受体。可能在脊髓灰质炎病毒的轴突运输中发挥作用,通过与 DYNLT1 相互作用,将含有病毒-PVR 的内囊泡定向到微管网络。这种相互作用将推动含病毒的囊泡向轴突逆向运输。 翻译后:N-糖基化。N-糖基化在 Asn-120:Hex5HexNAc4.连接后被 Src 激酶磷酸化在 ITIM 矩阵中的酪氨酸残基上。磷酸化需要与 TIGIT 相互作用。
生物活性
Testing in progress
来源
重组表达
预测分子量
35.9 kDa
蛋白标签
C-His
SDS-PAGE
50.0-71.7 kDa, under reducing conditions; 47.1-65.5 kDa, under non-reducing conditions
表达系统
HEK293 Accession #: P15151 | HEK293
内毒素水平
<1.0 EU/μg
种属
人(Human)
氨基酸
1-343 aa
序列
MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGISRNHHHHHH
无动物源
Yes
无载体
Yes
Safety
「No Dangerous Attributes」
Related
「No upstream and downstream information yet」
Technical Documents
「No technical documents」
Articles
「No related articles yet」
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Research chemical ≥95%

Research chemical ≥95%; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: ≥95%.

item number:rp181610-10μg
Product model:10μg
level: ≥95%
Lead Time:30days
sold 102 Items
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10μg

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