Recombinant Human SLAMF7/CRACC Protein

重组人SLAMF7/CRACC蛋白 | 重组人 SLAMF7/CRACC 蛋白

19A | CD2 subset 1 | CD2-like receptor activating cytotoxic cells | CD319 antigen | CD319 | CRACC | CRACCCD2-like receptor-activating cytotoxic cells | CS119A24 protein | Membrane protein FOAP-12 | novel LY9 (lymphocyte antigen 9) like protein | Novel Ly9

rp181619-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Protein Function: SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruit signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.

Testing in progress

重组表达

23.2 kDa

C-His

34.7-44.4 kDa, under reducing conditions; 34.7-44.4 kDa, under non-reducing conditions

HEK293 Accession #: Q9NQ25-1 | HEK293

<1.0 EU/μg

人(Human)

1-226 aa

MAGSPTCLTLIYILWQLTGSAASGPVKELVGSVGGAVTFPLKSKVKQVDSIVWTFNTTPLVTIQPEGGTIIVTQNRNRERVDFPDGGYSLKLSKLKKNDSGIYYVGIYSSSLQQPSTQEYVLHVYEHLSKPKVTMGLQSNKNGTCVTNLTCCMEHGEEDVIYTWKALGQAANESHNGSILPISWRWGESDMTFICVARNPVSRNFSSPILARKLCEGAADDPDSSMHHHHHH

Yes

Yes