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Product details

名称

Recombinant Human PBEF/Visfatin Protein

别名

重组人PBEF/Visfatin蛋白

英文别名

货号

rp183590-10μg

包装规格

10μg

级别

无载体

浓度

≥90%(SDS-PAGE)

生化机理

催化烟酰胺与 5-磷酸核糖基-1-焦磷酸缩合，生成烟酰胺单核苷酸，这是生物合成 NAD 的中间体。它是哺乳动物 NAD 生物合成途径中的限速成分。分泌型既是一种具有免疫调节特性的细胞因子，也是一种具有抗糖尿病特性的脂肪因子，它没有酶活性，部分原因是缺乏 ATP 的激活，而 ATP 在细胞外空间和血浆中的含量很低。在调节昼夜节律钟功能方面发挥作用。NAMPT 依赖于 NAD 的振荡产生，通过释放核心时钟成分来调节时钟目标基因表达的振荡：CLOCK-BMAL1异二聚体不受 NAD 依赖性 SIRT1 介导的抑制（相似）。

生物活性

Immobilized Recombinant Human PBEF/Visfatin Protein (rp183590) at 1.0 μg/mL can bind Recombinant Visfatin Antibody (Ab134271) with the EC50 of 4.18 ng/mL.

来源

重组表达

预测分子量

56.3 kDa

蛋白标签

N-His

SDS-PAGE

54.6 kDa, under reducing conditions; 54.6 kDa, under non-reducing conditions.

表达系统

E. coli Accession #: P43490 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

2-491 aa

序列

MHHHHHHNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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