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Product details
名称
Recombinant Human NM23-H1 Protein
别名
重组人NM23-H1蛋白 | 重组人NM23-H1蛋白
英文别名
EC 2.7.4.6 | GAAD | Granzyme A-activated DNase | Metastasis inhibition factor nm23 | NB | NBS | NDK A | NDKA | NDP kinase A | NDPKA | NDPK-A | NM23A | NM23AWD | Tumor metastatic process-associated protein | nucleoside diphosphate kinase A | NM23H1 | NM23-
货号
rp183591-10μg
包装规格
10μg
级别
无载体
浓度
≥95%(SDS-PAGE)
生化机理
NME1又称核苷二磷酸激酶A(NDK-A)或NM23-H1,属于NDK家族。众所周知,NM23-H1 在许多肿瘤细胞中具有抑制转移的活性。最近的研究表明,与 NM23-H1 相互作用的蛋白能介导细胞增殖,也可能是转移抑制活性的调节因子。与 NM23-H1 相互作用的蛋白质可分为三类。第一类蛋白可归为 NM23-H1 的上游激酶,如 CKI 和 Aurora-A/STK15。第二类蛋白在 Erk 信号级联中充当下游效应器,调节特定基因转录、GTP 结合蛋白功能和信号转导。第三类蛋白质可归类为 NM23-H1 的双向影响结合伙伴。因此,NM23-H1 与结合伙伴的相互作用对涉及转移和肿瘤发生的生化特征具有影响。NDKA 在人死后脑脊液(CSF)中增加,而脑脊液是脑部全面损伤的模型,这表明在脑脊液中,更重要的是在血浆中测量 NDKA 可作为中风的生物标志物。此外,NM23-H1 能显著减少转移,而不影响原发肿瘤的大小,是第一个被发现的转移抑制基因。
生物活性
Testing in progress
来源
重组表达
预测分子量
17.0 kDa
蛋白标签
No tag
SDS-PAGE
13.6-16.8 kDa, under reducing conditions; 13.6-16.8 kDa, under non-reducing conditions.
表达系统
E. coli Accession #: P15531 | E. coli
内毒素水平
<1.0 EU/μg
种属
人(Human)
氨基酸
2-152 aa
序列
ANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFHPEELVDYTSCAQNWIYE
无动物源
No
无载体
Yes
Safety
「No Dangerous Attributes」
Related
「No upstream and downstream information yet」
Technical Documents
「No technical documents」
Articles
「No related articles yet」
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Research chemical ≥95%

Research chemical ≥95%; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: ≥95%.

item number:rp183591-10μg
Product model:10μg
level: ≥95%
Lead Time:30days
sold 395 Items
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10μg

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