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名称

Recombinant Mouse Alpha-synuclein Protein

别名

重组小鼠Alpha-synuclein蛋白 | 重组小鼠α突触核蛋白

英文别名

货号

rp183595-10μg

包装规格

10μg

级别

无载体

浓度

≥95%(SDS-PAGE)

生化机理

Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associated with membranes and the other is disordered, cytosolic form. Synuclein is found predominantly in the presynaptic termini, in both free or membrane-bound forms. SNCA is extensively localized in nucleus of neurons. It has been shown that alpha-Synuclein was highly expressed in the mitochondria in olfactory bulb, hippocampus, striatum, and thalamus, where the cytosolic alpha-Synuclein was also rich. Normally the unstructured soluble type of alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. SNCA abnormality and mitochondrial deficiency are two major changes in the brain of patients with Parkinson's disease (PD). Besides, alpha-synuclein is an abundant component of Lewy bodies in sporadic Parkinson's disease and diffuse Lewy body disease. Post-translational: Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress. Ubiquitinated. The predominant conjugate is the diubiquitinated form. Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.

生物活性

Immobilized Recombinant Mouse Alpha-synuclein Protein (rp183595) at 1.0 μg/mL can bind Alpha-synuclein Mouse mAb (Ab185363) with the EC50 of 19.8 ng/mL. Immobilized Recombinant Mouse Alpha-synuclein Protein (rp183595) at 1.0 μg/mL can bind Alpha-synuclein Mouse mAb (Ab185365) with the EC50 of 28.3 ng/mL. Immobilized Recombinant Mouse Alpha-synuclein Protein (rp183595) at 5.0 μg/mL can bind Cinpanemab (anti-Alpha-synuclein) (Ab176594) with the EC50 of 475.3 ng/mL.

来源

重组表达

预测分子量

15.3 kDa

蛋白标签

C-His

SDS-PAGE

17.1 kDa, under reducing conditions; 17.1 kDa, under non-reducing conditions.

表达系统

E. coli Accession #: O55042 | E. coli

内毒素水平

<1.0 EU/μg

种属

小鼠(Mouse)

氨基酸

1-140 aa

序列

MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGNIAAATGFVKKDQMGKGEEGYPQEGILEDMPVDPGSEAYEMPSEEGYQDYEPEAHHHHHH

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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