Recombinant Human Carbonic Anhydrase XIII Protein

重组人Carbonic Anhydrase XIII蛋白 | 重组人碳酸酐酶13蛋白

CA13 | carbonic anhydrase 13 | Carbonic Anhydrase XIII | carbonic anhydrase XIIICarbonate dehydratase XIII | CAXIII | CA-XIII | EC 4.2.1.1 | FLJ37995 | MGC59868

rp183661-10μg

10μg

无载体

≥90%(SDS-PAGE)

The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons, a reversible reaction that takes part in maintaining acid-base balance in blood and other tissues. The carbonic anhydrasekl (CA) family consists of at least 11 enzymatically active members and a few inactive homologous proteins. The CAXIII is a member of the CA family, which owns a globular molecule with high structural similarity to cytosolic isozymes, CAI, II, and III. Recombinant mouse CAXIII showed catalytic activity similar to those of mitochondrial CAV and cytosolic CAI. In human tissues, CAXIII expression was identified in the thymus, small intestine, spleen, prostate, ovary, colon, and testis. In mouse, positive tissues included the spleen, lung, kidney, heart, brain, skeletal muscle, and testis. In conclusion, the predicted amino acid sequence, structural model, distribution, and activity data suggest that CAXIII represents a novel enzyme, which may play important physiological roles in several organs.

Measured by its esterase activity. The specific activity is >5 pmol/min/µg, as measured under the described conditions.

重组表达

30.8 kDa

C-10His

30.5 kDa, under reducing conditions; 30.5 kDa, under non-reducing conditions.

E. coli Accession #: Q8N1Q1 | E. coli

<1.0 EU/μg

人(Human)

1-262 aa

MSRLSWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASFHHHHHHHHHHH

No

Yes