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Product details

名称

Recombinant Human CCL3L1/LD78 beta Protein

别名

重组人CCL3L1/LD78 beta蛋白 | 重组人CCL3样蛋白1

英文别名

货号

rp183664-10μg

包装规格

10μg

级别

无载体

浓度

≥95%(SDS-PAGE)

生化机理

The macrophage inflammatory protein-1 alpha (MIP-1 alpha )/CCL3 and-1 beta (MIP-1 beta )/CCL4 are highly homologous CC family chemokines that were originally co-purified from medium conditioned by an LPS-stimulated murine macrophage cell line. Mouse MIP-1 alpha and MIP-1 beta are encoded by their respective single-copy genes. In human, additional non-allelic MIP-1 alpha and MIP-1 beta genes also exist. The two human MIP-1 alpha genes arise by duplication/mutation. They code for MIP-1 alpha isoforms CCL3/LD78 alpha and CCL3L1/LD78 beta, which share 94% amino acid (aa) sequence homology. Whereas the human CCL3/LD78 alpha is a single-copy gene, the human CCL3L1/LD78 beta gene copy number varies within the population. Human CCL3L1/LD78 beta cDNA encodes a 93 aa residue precursor with a 23 aa residue signal peptide that is cleaved to generate a 70 aa mature protein. Human CCL3L1/LD78 beta binds and signals through chemokine receptors CCR1 and CCR5. When compared to CCL3/LD78 alpha, CCL3L1/LD78 beta has higher binding affinity to CCR5, which also functions as a coreceptor for HIV-1 entry. The copy number of CCL3L1 is one of several genetic determinants of HIV-1 susceptibility. Post-translational: The N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is probably achieved by DPP4.

生物活性

Determined by its ability to chemoattract human monocytes using a concentration range of 0 - 5.0 ng/mL.

来源

重组表达

预测分子量

22.1 kDa

蛋白标签

No tag

SDS-PAGE

10.0 & 16.8 kDa, under reducing conditions; 10.8 & 19.0 kDa, under non-reducing conditions.

表达系统

E. coli Accession #: P16619 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

24-93 aa

序列

GAPLAADTPTACCFSYTSRQIPQNFIADYFETSSQCSKPSVIFLTKRGRQVCADPSEEWVQKYVSDLELSA

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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