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Product details

名称

Recombinant Human FGF-18 Protein

别名

重组人FGF-18蛋白 | 重组人成纤维生长因子18蛋白

英文别名

FGF18 | FGF-18 | FGF-18ZFGF5 | fibroblast growth factor 18 | zFGF5

货号

rp183678-10μg

包装规格

10μg

级别

无载体

浓度

≥95%(SDS-PAGE)

生化机理

Fibroblast Growth Factor 18 (FGF-18) is a 20 kDa protein that plays an important role in skeletal development and bone homeostasis. Mature human FGF-18 shares 99% amino acid sequence identity with mouse and rat FGF-18. It is expressed in embryonic somites and the neural fold, adult lung, cerebellar and hippocampal neurons, hair follicle root sheath cells, and osteogenic mesenchymal cells. FGF-18 binds to FGF R2c, FGF R3c as well as the Golgi protein GLG1 and induces the proliferation of astrocytes and microglia, vascular endothelial cells, dermal fibroblasts, papilla cells, and keratinocytes. FGF-18 is required for normal skeletal development. It recruits osteoclasts and osteoblasts to the growth plate, promotes osteoclast formation and function, inhibits osteoblast differentiation, promotes skeletal vascularization, and induces chondrocyte hypertrophy and cartilage matrix formation.

生物活性

Measured in a cell proliferation assay using BALB/3T3 mouse embryo fibroblasts cell. The ED50 for this effect is 6.91ng/mL.

来源

重组表达

预测分子量

21.0 kDa

蛋白标签

No tag

SDS-PAGE

18.1 kDa, under reducing conditions; 18.1 kDa, under non-reducing conditions.

表达系统

E. coli Accession #: O76093 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

28-207 aa

序列

EENVDFRIHVENQTRARDDVSRKQLRLYQLYSRTSGKHIQVLGRRISARGEDGDKYAQLLVETDTFGSQVRIKGKETEFYLCMNRKGKLVGKPDGTSKECVFIEKVLENNYTALMSAKYSGWYVGFTKKGRPRKGPKTRENQQDVHFMKRYPKGQPELQKPFKYTTVTKRSRRIRPTHPA

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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