Recombinant Human HPGDS Protein

重组人HPGDS蛋白 | 重组人造血前列腺素D合成酶

EC 2.5.1.18 | EC 5.3.99.2 | glutathione S-transferase sigma | Glutathione S-transferase | Glutathione-dependent PGD synthase | Glutathione-requiring prostaglandin D synthase | GST class-sigma | GSTS | GSTShematopoietic prostaglandin D2 synthase | hematopo

rp183686-10μg

10μg

无载体

≥95%(SDS-PAGE)

Prostaglandin D Synthase (PGDS) catalyzes the conversion of prostaglandin (PG) H2 to PGD2, which is a major prostanoid produced in a variety of tissues. Two types of PGDS have been isolated; the glutathione-dependent hematopoietic PGDS (HPGDS) and the glutathione-independent lipocalin-type PGDS. HPGDS is a cytosolic enzyme that is expressed in mast cells and antigen presenting cells. It is the only mammalian member of the class Sigma glutathione S-transferase, showing a broad specificity towards standard transferase substrates. The PGD2 produced by HPGDS is involved in many physiological processes such as maintaining body temperature, promoting sleep, inhibiting platelet aggregation, and bronchoconstriction. It also functions in immune response and acts as a mediator in allergy and inflammation. HPGDS-specific inhibitors may be therapeutically useful as anti-allergic and anti-inflammatory drugs.

Measured by the conjugation of reduced glutathione to 1-Chloro-2,4-dinitrobenzene. The specific activity is >650 pmol/min/μg, as measured under the described conditions.

重组表达

24.1 kDa

C-His

23.3 kDa, under reducing conditions; 23.3 kDa, under non-reducing conditions.

E. coli Accession #: O60760 | E. coli

<1.0 EU/μg

人(Human)

1-199 aa

MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKLHHHHHH

No

Yes