Recombinant Human 6-Phosphogluconate Dehydrogenase/PGD Protein

重组人6-Phosphogluconate Dehydrogenase/PGD蛋白 | 重组人6-磷酸葡萄糖酸脱氢酶蛋白

6PGD | EC 1.1.1.44,6-phosphogluconate dehydrogenase, decarboxylating | PGD | PGDH | phosphogluconate dehydrogenase

rp183691-10μg

10μg

无载体

≥90%(SDS-PAGE)

6-phosphogluconate dehydrogenase (PGD) is the second dehydrogenase in the pentose phosphate pathway. It catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH. Together with glucose-6-phosphate dehydrogenase (G6PD), these enzymes ensure the reducing environment of the cell cytoplasm. However, the activities of both enzymes are strongly inhibited by NADPH. It is not quite clear how the enzymes are regulated to maintain the level of reducing power inside cells. Deficiency of PGD is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of PGD and 6-phosphogluconolactonase suggest a synergism of the two enzymopathies.

重组表达

58.0 kDa

N-His

50.4 kDa, under reducing conditions; 50.4 kDa, under non-reducing conditions.

E. coli Accession #: P52209 | E. coli

<1.0 EU/μg

人(Human)

2-483 aa

MHHHHHHSSGLVPRGSGMKETAAAKFERQHMDSPDLGTENLYFQGAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKVGTGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFIHTNWTGHGGTVSSSSYNA​

No

Yes