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Product details

名称

Recombinant Human Stathmin 1 Protein

别名

重组人Stathmin 1蛋白 | 重组人 Stathmin 1 蛋白

英文别名

C1orf215 | Lag | LAP 18 | LAP18 | Leukemia associated phosphoprotein p18 | Leukemia-associated phosphoprotein p18 | Metablastin | Oncoprotein 18 | OP 18 | Op18 | p18 | p19 | Phosphoprotein 19 | STMN1_HUMAN | Stmn1 | STMN 1 | Stathmin1 | Stathmin | SMN | P

货号

rp183706-10μg

包装规格

10μg

级别

无载体

浓度

≥95%(SDS-PAGE)

生化机理

Stathmin1（STMN1）是一种调节细胞微管动力学的细胞膜磷酸蛋白，已知具有致癌活性。STMN1 可能是葛兰癌患者对紫杉醇敏感和预后不良的生物标志物，也可能是转移性葛兰癌的新型治疗靶点。STMN1 的表达可作为确定非典型脑膜瘤患者预后的生物标志物。Stathmin1（STMN1）是一种细胞膜蛋白，通过抑制微管蛋白聚合和促进微管解聚参与微管动力学。据报道，抑制 Stathmin 1 (STMN1) 可降低细胞活力和迁移潜力。STMN1 可能是 PDAC 靶向治疗的一个有希望的候选靶点。通过破坏微管的稳定性参与微管（MT）丝系统的调控。阻止微管的组装并促进其解体。神经发生过程中轴突的形成可能需要 Ser-16 处的磷酸化。参与控制习得性恐惧和先天性恐惧（相似）。翻译后：根据可被磷酸化的位点之间的特定组合，可观察到许多不同的磷酸化形式。MAPK 负责使 stathmin 对 NGF 产生磷酸化反应。Ser-16 处的磷酸化似乎是神经元极化所必需的（相似性）。Ser-63 处的磷酸化可使管蛋白结合率降低 10 倍，并抑制 MT 聚合抑制活性。

生物活性

Testing in progress

来源

重组表达

预测分子量

18.1 kDa

蛋白标签

N-His

SDS-PAGE

16.2 kDa, under reducing conditions; 16.2 kDa, under non-reducing conditions.

表达系统

E. coli Accession #: P16949 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

2-149 aa

序列

MHHHHHHASSDIQVKELEKRASGQAFELILSPRSKESVPEFPLSPPKKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFSKMAEEKLTHKMEANKENREAQMAAKLERLREKDKHIEEVRKNKESKDPADETEAD

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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Consultation

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