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Product details

名称

Recombinant Human KMT6/EZH2 Protein

别名

重组人Legumain/Asparaginyl Endopeptidase蛋白 | 重组人天冬酰胺内肽酶蛋白

英文别名

Enhancer of zeste 2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | Enhancer of zeste homolog 2 | Enhancer of zeste homolog 2 (Drosophila) | Enhancer of zeste, Drosophila, homolog 2 | ENX 1 | Enx 1h | ENX-1 | ENX1 | Enx1h | EZH 2 | EZH1 | EZ

货号

rp183733-10μg

包装规格

10μg

级别

无载体

浓度

≥80%(SDS-PAGE)

生化机理

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. Post-translational: Phosphorylated by AKT1. Phosphorylation by AKT1 reduces methyltransferase activity. Phosphorylation at Thr-345 by CDK1 and CDK2 promotes maintenance of H3K27me3 levels at EZH2-target loci, thus leading to epigenetic gene silencing. Sumoylated. Glycosylated: O-GlcNAcylation at Ser-75 by OGT increases stability of EZH2 and facilitates the formation of H3K27me3 by the PRC2/EED-EZH2 complex.

生物活性

Immobilized Recombinant Human KMT6/EZH2 Protein (rp183733) at 1.0 μg/mL can bind Recombinant KMT6/EZH2 Antibody (Ab112346) with the EC50 of 3.1 ng/mL.

来源

重组表达

预测分子量

44.2 kDa

蛋白标签

No tag

SDS-PAGE

47.1 kDa, under reducing conditions

表达系统

E. coli Accession #: Q15910 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

2-385 aa

序列

GQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAG

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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