Recombinant Human Lactate Dehydrogenase A/LDHA Protein

重组人Lactate Dehydrogenase A/LDHA蛋白 | 重组人乳酸脱氢酶A蛋白

Cell proliferation-inducing gene 19 protein | EC 1.1.1 | EC 1.1.1.27 | GSD11 | Lactate Dehydrogenase A | lactate dehydrogenase M | LDH muscle subunit | LDH1 | LDHA | LDH-A | LDHM | LDH-M | L-lactate dehydrogenase A chain | proliferation-inducing gene 19 |

rp183741-10μg

10μg

无载体

≥95%(SDS-PAGE)

A hallmark of most cancer cells is an altered metabolism involving a shift to aerobic glycolysis with lactate production coupled with a higher uptake of glucose as the main source of energy. Lactate dehydrogenase (LDH) is key to this shift by catalyzing the formation of lactate by reducing pyruvate with NADH, which also generates NAD(+) that is essential for the continuity of glycolysis. LDHA is a key enzyme that controls the production of lactate in the glycolysis pathway. It is therefore an important control point in the system of cellular energy release. It's up regulation is common in many malignant tumors. Inhibiting LDH activity has an anti-proliferative effect on cancer cells. It may reverse the resistance of tumor cells to conventional chemo- and radiotherapy. Recent research has renewed interest in LDH as an anticancer drug target. The protein is found predominantly in muscle tissue. Mutations in LDHA have been linked to exertional myoglobinuria. Post-translational: ISGylated

Measured by its ability to reduce pyruvate (S670383) to lactate. The specific activity is > 95,000 pmol/min/μg.

重组表达

37.5 kDa

N-His

34.5 kDa, under reducing conditions; 34.5 kDa, under non-reducing conditions

E. coli Accession #: P00338 | E. coli

<1.0 EU/μg

人(Human)

2-332 aa

MHHHHHHATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF​

No

Yes