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Product details

名称

Recombinant Human L1CAM Protein

别名

重组人L1CAM蛋白 | 重组人L1-细胞粘附分子蛋白 | 重组人L1CAM蛋白 | 重组人L1-细胞粘附分子蛋白 | 重组人类 L1CAM 蛋白

英文别名

货号

rp184061-10μg

包装规格

10μg

级别

无动物源

浓度

≥95%(SDS-PAGE)

生化机理

L1 细胞粘附分子（L1CAM），又称 CD171，是免疫球蛋白超家族的一种细胞粘附受体，因其在神经细胞功能中的作用而闻名。虽然最初认为 L1-CAM 只存在于脑细胞中，但近年来在其他组织和各种癌细胞中也检测到了 L1-CAM，包括一些常见类型的人类癌症。L1CAM 与多种配体相互作用，包括轴突蛋白-1、CD9、神经凝集素和整合素，研究发现 L1CAM 第六个 Ig 结构域中的 RGD 矩阵是整合素的结合位点，因此对核信号转导非常重要。L1CAM 功能的中断会导致三种 X 连锁神经综合征，即脑积水、MASA 综合征（智力迟钝、失语、步态不整齐和拇指内收）和痉挛性截瘫综合征。在正常细胞和癌细胞中过表达 L1CAM 会增加细胞的运动性，提高生长速度，促进细胞转化和致瘤性。最近的研究发现，L1CAM（CD171）是人类癌症进展的新型标志物，也是抗癌疗法的候选对象。

生物活性

Measured by the ability of the immobilized protein to support the adhesion of SK-N-SH neuroblastoma cancer cell. When 1x 104 cells/well are added to Recombinant Human L1CAM Protein (rp184061) coated plates (15 µg/mL with 100 µL/well), >30% will adhere for 2 hour incubation at 37 °C. .

来源

重组表达

预测分子量

124 kDa

蛋白标签

C-His

SDS-PAGE

162.3-226.7 kDa, under reducing conditions; 161.3-228.6 kDa, under non-reducing conditions

表达系统

HEK293 Accession #: P32004 | HEK293

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

1-1120 aa

序列

MVVALRYVWPLLLCSPCLLIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQPDTDYEIHLFKERMFRHQMAVKTNGTGRVRLPPAGFATEHHHHHH

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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