Recombinant Human Tyro3/Dtk Protein

重组人Tyro3/Dtk蛋白 | 重组人 Tyro3/Dtk 蛋白

BYK | Brt | Dtk | EC 2.7.10 | EC 2.7.10.1 | FLJ16467 | Rse | Sky | Tif | TYRO3 protein tyrosine kinase | Tyro3 | Tyrosine-protein kinase byk | Tyrosine-protein kinase DTK | tyrosine-protein kinase receptor TYRO3 | Tyrosine-protein kinase RSE | Tyrosine-pr

rp184087-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Protein Function:： Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. The binding affinities for Gas6 is in the order of Axl > Dtk > Mer. Gas6 binding induces tyrosine phosphorylation and downstream signaling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis. Dtk is widely expressed during embryonic development. In adults, Dtk is predominantly expressed in neurons in restricted regions of the brain.

Testing in progress

重组表达

42.4 kDa

C-His

52.7-64.6 kDa, under reducing conditions; 51.1-61.3 kDa, under non-reducing conditions

HEK293 Accession #: Q06418 | HEK293

<1.0 EU/μg

人(Human)

1-428 aa

MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSHHHHHH​

Yes

Yes