Recombinant Human Cystatin-B Protein

重组人Cystatin-B蛋白 | 重组人半胱氨酸蛋白酶抑制剂B蛋白 | 重组人胱抑素-B蛋白

CPI-B | CST6cystatin B (liver thiol proteinase inhibitor)10STFBcystatin-B | CSTB | cystatin B (stefin B) | Cystatin B | EPM1 | Liver thiol proteinase inhibitor | PME | Stefin B | stefin-B

rp184103-10μg

10μg

无载体

≥95%(SDS-PAGE)

Cystatin-B, also known as CPI-B, Liver thiol proteinase inhibitor, Stefin-B, CSTB and CST6, is a cytoplasm and nucleus protein which belongs to thecystatin family. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the proteases leaking from lysosomes. Defects in Cystatin-B / CSTB are the cause of progressive myoclonic epilepsy type 1 (EPM1) which is an autosomal recessive disorder characterized by severe, stimulus-sensitive myoclonus and tonic-clonic seizures. The cystatins are a family of cysteine protease inhibitors with homology to chicken cystatin. Cystatins are physiological inhibitors of cysteine proteinases which are widely distributed in human tissues and fluids. Cystatins typically comprise about 115 amino acids, are largely acidic, contain four conserved cysteine residues known to form two disulfide bonds. Cystatins may be glycosylated and / or phosphorylated, with similarity to fetuins, kininogens, stefins, histidine-rich glycoproteins and cystatin-related proteins. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired inhibitory activity. Cystatins mainly inhibit peptidases belonging to peptidase families C1 (papain family) and C13 (legumain family).

Immobilized Recombinant Human Cystatin-B Protein (rp184103) at 1.0 μg/mL can bind Cystatin-B Antibody (Ab098665) with the EC50 of 4.3 ng/mL.

重组表达

11.9 kDa

N-His

12.8 & 28.6 kDa, under reducing conditions; 13.0 & 27.7 kDa, under non-reducing conditions.

E. coli Accession #: P04080 | E. coli

<1.0 EU/μg

人(Human)

2-98 aa

MHHHHHHMCGAPSATQPATAETQHIADQVRSQLEEKENKKFPVFKAVSFKSQVVAGTNYFIKVHVGDEDFVHLRVFQSLPHENKPLTLSNYQTNKAKHDELTYF​

No

Yes