Recombinant Human VE-Cadherin Protein

重组人VE-Cadherin蛋白 | 重组人VE-钙粘蛋白

7B4 | 7B4 antigen | cadherin 5, type 2 (vascular endothelium) | cadherin 5, type 2, VE-cadherin (vascular epithelium) | Cadherin-5 | CD144 antigen | CD144 | CDH5 | endothelial-specific cadherin | FLJ17376 | Vascular endothelial cadherin | VECadherin | VE-

rp184119-10μg

10μg

无动物源

≥90%(SDS-PAGE)

Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.

Measured by the ability of the immobilized protein to support the adhesion of HUVEC cells. The ED50 for this effect is 308.4ng/mL. Measured by the ability of the immobilized protein to support the adhesion of HUVEC human umbilical vein endothelial cells, When 3 x 104 cells per well are added to Recombinant Human VE-Cadherin Protein (rp184119) coated plates (370 ng/mL, 100 μL/well) can significantly improve cells adhesion.

重组表达

67.5 kDa

C-His

82.0-98.0 kDa, under reducing conditions; 82.0-98.0 kDa, under non-reducing conditions

HEK293 Accession #: P33151 | HEK293

<1.0 EU/μg

人(Human)

1-593 aa

MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQHHHHHH

Yes

Yes