Recombinant Human CDK1 Protein

重组人CDK1蛋白 | 重组人类 CDK1 蛋白

Cdc2 | Cdc 2 | CDC28A | CDK 1 | CDK1 | CDK1_HUMAN | CDKN1 | CELL CYCLE CONTROLLER CDC2 | Cell division control protein 2 | Cell division control protein 2 homolog | Cell division cycle 2 G1 to S and G2 to M | Cell division protein kinase 1 | Cell Divsion

rp184120-10μg

10μg

无载体

≥90%(SDS-PAGE)

CDC2, also known as CDK1, contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily. CDC2 is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with CDC2 and function as regulatory subunits. The kinase activity of CDK1 is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of CDC2 also play important regulatory roles in cell cycle control. It is required in higher cells for entry into S-phase and mitosis. CDC2 also is a cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. It has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. CDK1 is required for RNA splicing, possibly by phosphorylating SRSF1/SF2. It is involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors. Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.

Immobilized Recombinant Human CDK1 Protein (rp184120) at 1.0 μg/mL can bind Recombinant CDK1 Antibody (Ab095719) with the EC50 of 3.0 ng/mL.

重组表达

34.9 kDa

N-His

31.6 kDa, under reducing conditions.

E. coli Accession #: P06493 | E. coli

<1.0 EU/μg

人(Human)

2-297 aa

MHHHHHHEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM

No

Yes