Recombinant Human ZEB1 Protein

重组人ZEB1蛋白 | 重组人E盒结合锌指蛋白 | 重组人锌指E盒结合同源蛋白1

AREB 6 | AREB6 | BZP | Delta crystallin enhancer binding factor 1 | DELTA EF1 | FECD6 | MGC133261 | Negative regulator of IL 2 | Negative regulator of IL2 | NIL 2 A | NIL 2 A zinc finger protein | NIL 2A | NIL-2-A zinc finger protein | NIL2A | Posterior p

rp184861-10μg

10μg

无载体

≥90%(SDS-PAGE)

Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). Post-translational: Ubiquitinated, leading to degradation in a proteasome-dependent manner. Deubiquitinated by USP51, leading to stabilization.

Immobilized Recombinant Human ZEB1 Protein (rp184861) at 1.0 μg/mL can bind Recombinant ZEB1 Antibody (Ab135194) with the EC50 of 4.2 ng/mL.​

重组表达

40.4 kDa

N-His

60.2 kDa, under reducing conditions

E. coli Accession #: P37275 | E. coli

<1.0 EU/μg

人(Human)

2-350 aa

MHHHHHHADGPRCKRRKQANPRRNNVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDDLPTDQTVLPGRSSEREGNAKNCWEDDRKEGQEILGPEAQADEAGCTVKDDECESDAENEQNHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGYKRFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEP​

No

Yes