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Product details
名称
Recombinant Human UBE2S Protein
别名
重组人UBE2S蛋白 | 重组人泛素结合酶E2-S | 重组人 UBE2S 蛋白
英文别名
AA409170 | E2 EPF | E2-EPF | E2EPF | EPF5 | MGC101982 | Ube2s | UBE2S_HUMAN | Ubiquitin carrier protein S | Ubiquitin conjugating enzyme E2 24 kD | Ubiquitin conjugating enzyme E2 24 kDa | Ubiquitin conjugating enzyme E2 EPF5 | Ubiquitin conjugating enzym
货号
rp184866-10μg
包装规格
10μg
级别
无载体
浓度
≥90%(SDS-PAGE)
生化机理
接受 E1 复合物中的泛素,并催化其与其他蛋白质的共价连接。催化'Lys-11'连接的多泛素化。作为无丝分裂促进复合体/环体(APC/C)的重要因子,APC/C 是一种受细胞周期调控的泛素连接酶,可控制有丝分裂的进程。其作用是特异性地拉长由 APC/C 底物上的 E2 酶 UBE2C/UBCH10 启动的'Lys-11'连接的多泛素链,加强蛋白酶体对 APC/C 底物的降解,促进有丝分裂的结束。在体外还通过延长由 E2 酶 UBE2D1/UBCH5 启动的泛素链发挥作用;但目前还不清楚 UBE2D1/UBCH5 在体内是否充当 APC/C 的 E2 酶。还参与 VHL 的泛素化和随后的降解,导致 HIF1A 的积累。在体外,除了'Lys-48'连接的多泛素化外,它能利用所有 7 个泛素 Lys 残基促进多泛素化。 翻译后:在 G1 期间被 APC/C 复合物自泛素化,导致其被蛋白酶体降解。
生物活性
Testing in progress
来源
重组表达
预测分子量
24.6 kDa
蛋白标签
N-His
SDS-PAGE
27.8 kDa, under reducing conditions; 27.8 kDa, under non-reducing conditions
表达系统
E. coli Accession #: Q16763 | E. coli
内毒素水平
<1.0 EU/μg
种属
人(Human)
氨基酸
2-222 aa
序列
MHHHHHHNSNVENLPPHIIRLVYKEVTTLTADPPDGIKVFPNEEDLTDLQVTIEGPEGTPYAGGLFRMKLLLGKDFPASPPKGYFLTKIFHPNVGANGEICVNVLKRDWTAELGIRHVLLTIKCLLIHPNPESALNEEAGRLLLENYEEYAARARLLTEIHGGAGGPSGRAEAGRALASGTEASSTDPGAPGGPGGAEGPMAKKHAGERDKKLAAKKKTDKKRALRRL
无动物源
No
无载体
Yes
Safety
「No Dangerous Attributes」
Related
「No upstream and downstream information yet」
Technical Documents
「No technical documents」
Articles
「No related articles yet」
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Research chemical ≥90%

Research chemical ≥90%; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: ≥90%.

item number:rp184866-10μg
Product model:10μg
level: ≥90%
Lead Time:30days
sold 666 Items
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10μg

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