Recombinant Mouse CXCL17/VCC-1 Protein

重组小鼠CXCL17/VCC-1蛋白 | 重组小鼠CXC基序趋化因子配体17蛋白

Chemokine (C-X-C Motif) Ligand 17 | C-X-C Motif Chemokine 17 | CXCL17 | Dcip1 | Dendritic Cell And Monocyte Chemokine-Like Protein | DMC | UNQ473 | VCC1 | VCC-1 | VEGF Coregulated Chemokine 1 | VEGF Co-Regulated Chemokine 1

rp184867-10μg

10μg

无载体

≥90%(SDS-PAGE)

Dendritic cell and monocyte chemokine-like protein (DMC), also known as VEGF-correlated chemokine-1 (VCC-1), is a secreted molecule with a size and predicted three-dimensional folding pattern similar to that of chemokines CXCL8/IL-8 and CXCL14/BRAK. It has no predicted N-glycosylation sites, so cleavage of a 22 amino acid (aa) signal sequence likely results in a mature mouse DMC molecule of 97 aa and 11 kDa size. DMC is constitutively produced by airway and intestinal epithelium. It induces the chemotaxis of quiescent, but not LPS‑activated peripheral blood monocytes and dendritic cells, and also binds these cells specifically (1). DMC expression is increased in endothelial cells when they are induced to form tubes in vitro. Transgenic overexpression in NIH3T3 cells causes up‑regulation of proteins such as VEGF and FGF basic, and increases cell growth rate and tumorigenicity. DMC and two other chemokines that play roles in angiogenesis, CXCL1/GRO and CXCL8/IL-8, show significantly correlated expression with that of VEGF in primary lung, breast and esophageal tumors. DMC is therefore suggested to play a role in tumor angiogenesis. Mature mouse DMC shares 82%, 71% and 66% amino acid sequence identity with rat, human and bovine DMC, respectively. Post-translational: Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion.

重组表达

13.4 kDa

N-His

10.1-18.1 kDa, under reducing conditions; 10.0-18.6 kDa, under non-reducing conditions.

E. coli Accession #: Q5UW37 | E. coli

<1.0 EU/μg

小鼠(Mouse)

23-119 aa

MGSSHHHHHHSSGENLYFQ/SPNPGVARSHGDQHLAPRRWLLEGGQECECKDWFLQAPKRKATAVLGPPRKQCPCDHVKGREKKNRHQKHHRKSQRPSRACQQFLKRCHLASFALPL

No

Yes