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Product details
名称
Recombinant Mouse IL-1 alpha/IL-1F1 Protein
别名
重组鼠IL-1 alpha/IL-1F1蛋白 | 重组小鼠 IL-1 α/IL-1F1 蛋白
英文别名
BAF | Hematopoietin-1 | IL1 alpha | IL-1 alpha | IL1 | IL1A | IL-1A | IL1-ALPHA | IL1F1 | IL-1F1 | IL1F1hematopoietin-1 | interleukin 1, alpha | interleukin-1 alpha | LAF | LEM | preinterleukin 1 alpha | pro-interleukin-1-alpha
货号
rp186521-10μg
包装规格
10μg
级别
无载体
浓度
≥95%(SDS-PAGE)
生化机理
IL-1 alpha 是白细胞介素 1 细胞因子家族的成员。细胞因子是一种蛋白质信号化合物,是免疫反应的主要介质。它们控制着许多不同的细胞功能,包括增殖、分化和细胞存活/凋亡,但也参与了一些病理生理过程,包括病毒感染和自身免疫性疾病。细胞因子由先天性免疫系统(单核细胞、巨噬细胞、树突状细胞)和适应性免疫系统(T 细胞和 B 细胞)的各种细胞在各种刺激下合成。细胞因子可分为两类:促炎细胞因子和抗炎细胞因子。促炎细胞因子包括 IFNgamma、IL-1、IL-6 和 TNF-α,主要来自先天性免疫细胞和 Th1 细胞。抗炎细胞因子(包括 IL-10、IL-4、IL-13 和 IL-5)由 Th2 免疫细胞合成。IL-1 alpha 是一种多效应细胞因子,参与各种免疫反应、炎症过程和造血。它由单核细胞和巨噬细胞产生,作为一种原蛋白,在细胞损伤时被蛋白水解并释放出来,从而诱导细胞凋亡。IL-1 alpha 可通过诱导 IL-2 释放、B 细胞成熟和增殖以及成纤维细胞生长因子活性来刺激胸腺细胞增殖。 翻译后:在其核定位序列内被乙酰化,从而影响亚细胞定位。从 31 kDa 的前体裂解为 18 kDa 的生物活性分子。磷酸化可大大提高消化敏感性,并促进前 IL1A alpha 转化为具有生物活性的 IL1A。
生物活性
Testing in progress
来源
重组表达
预测分子量
17.9 kDa
蛋白标签
No tag
SDS-PAGE
15.1 kDa, under reducing conditions; 15.1 kDa, under non-reducing conditions.
表达系统
E. coli Accession #: P01582 | E. coli
内毒素水平
<1.0 EU/μg
种属
小鼠(Mouse)
氨基酸
115-270 aa
序列
SAPYTYQSDLRYKLMKLVRQKFVMNDSLNQTIYQDVDKHYLSTTWLNDLQQEVKFDMYAYSSGGDDSKYPVTLKISDSQLFVSAQGEDQPVLLKELPETPKLITGSETDLIFFWKSINSKNYFTSAAYPELFIATKEQSRVHLARGLPSMTDFQIS
无动物源
No
无载体
Yes
Safety
「No Dangerous Attributes」
Related
「No upstream and downstream information yet」
Technical Documents
「No technical documents」
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「No related articles yet」
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Research chemical ≥95%

Research chemical ≥95%; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: ≥95%.

item number:rp186521-10μg
Product model:10μg
level: ≥95%
Lead Time:30days
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