Share to
Details
Safety
Related
Technical Documents
Articles
reviews
Consult
returns
Product details
名称
Recombinant Porcine IL-1 beta/IL-1F2 Protein
别名
重组猪IL-1 beta/IL-1F2蛋白 | 重组猪白细胞介素1β | 重组猪 IL-1 beta/IL-1F2 蛋白
英文别名
catabolin | IL1 beta | IL-1 beta | IL-1 | IL1B | IL-1b | IL1-BETA | IL-1F2 | IL1F2IL-1 beta | interleukin 1, beta | interleukin-1 beta | preinterleukin 1 beta | pro-interleukin-1-beta
货号
rp186524-10μg
包装规格
10μg
级别
无载体
浓度
≥95%(SDS-PAGE)
生化机理
IL-1 是指两种多效细胞因子,即 IL-1 alpha(IL-1F1)和 IL-1 beta(IL-1F2),它们是不同基因的产物。IL-1 alpha 和 IL-1 beta 是结构相关的多肽,在猪体内大约有 27% 的氨基酸 (aa) 相同。这两种蛋白质都是由多种细胞在炎症因子、感染或微生物内毒素作用下产生的。虽然 IL-1 alpha 和 IL-1 beta 是独立调节的,但它们与相同的受体结合并产生相同的生物效应。IL-1 RI 直接与 IL-1 alpha 或 IL-1 beta 结合,然后与 IL-1 R 辅助蛋白(IL-1 R3/IL-1 R AcP)结合,形成高亲和力的受体复合物,能够进行信号转导。IL-1 RII 对 IL-1 beta 具有高亲和力,但其功能是诱饵受体和 IL-1 beta 活性的负调节剂。IL-1ra 通过阻止 IL-1 alpha 和 IL-1 beta 与 IL-1 RI 相互作用而发挥竞争性拮抗剂的作用。猪 IL-1 beta cDNA 编码 267 aa 的前体。114 aa 的前肽在细胞内被半胱氨酸蛋白酶 IL-1 beta 转换酶(Caspase-1/ICE)裂解,生成活性细胞因子。17 kDa 的成熟猪 IL-1 beta 与犬、棉鼠、马、猫、人、小鼠、大鼠和恒河猴 IL-1 beta 有 63%-70% 的 aa 序列相同性。
生物活性
Testing in progress
来源
重组表达
预测分子量
17.5 kDa
蛋白标签
No tag
SDS-PAGE
16.4 kDa, under reducing conditions; 16.4 kDa, under non-reducing conditions
表达系统
E. coli Accession #: P26889 | E. coli
内毒素水平
<1.0 EU/μg
种属
猪(Porcine)
氨基酸
115-267 aa
序列
ANVQSMECKLQDKDHKSLVLAGPHMLKALHLLTGDLKREVVFCMSFVQGDDSNNKIPVTLGIKGKNLYLSCVMKDNTPTLQLEDIDPKRYPKRDMEKRFVFYKTEIKNRVEFESALYPNWYISTSQAEQKPVFLGNSKGRQDITDFTMEVLSP
无动物源
No
无载体
Yes
Safety
「No Dangerous Attributes」
Related
「No upstream and downstream information yet」
Technical Documents
「No technical documents」
Articles
「No related articles yet」
user reviews
Loading...
Consultation

Warm reminder:

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.!

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ,We will handle it for you as soon as possible, thank you for your support and trust.!

Research chemical ≥95%

Research chemical ≥95%; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: ≥95%.

item number:rp186524-10μg
Product model:10μg
level: ≥95%
Lead Time:30days
sold 236 Items
Ask Solution engineer
Specifications:

10μg

Qty

Recommended for you