Recombinant Human ATP1A1 Protein

重组人ATP1A1蛋白 | 重组人ATPase Na+/K+ 转运亚基 alpha 1蛋白

ATP1A1

rp186569-10μg

10μg

无载体

≥90%(SDS-PAGE)

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). Post-translational: Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity (By similarity).

Immobilized Recombinant Human ATP1A1 Protein (rp186569) at 1.0 μg/mL can bind ATP1A1 Mouse mAb (Ab088306) with the EC50 of 20.9 ng/mL.

重组表达

37.6 kDa

N-His

34.7 kDa, under reducing conditions; 33.3 kDa, under non-reducing conditions.

E. coli Accession #: P05023 | E. coli

<1.0 EU/μg

人(Human)

347-681 aa

MHHHHHHTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDI​

No

Yes