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Product details

名称

Recombinant Rat CNTF Protein

别名

重组大鼠CNTF蛋白 | 重组大鼠睫状神经营养因子

英文别名

ciliary neurotrophic factor | CNTF | HCNTF

货号

rp186591-10μg

包装规格

10μg

级别

无载体

浓度

≥95%(SDS-PAGE)

生化机理

Ciliary neurotrophic factor (CNTF) is a member of the cytokine family. It is a polypeptide hormone that has functions in promoting neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. Its actions appear to be restricted to the nervous system. Ciliary neurotrophic factor (CNTF) has biological effects through the activation of a multi-subunit receptor complex, consisting of an extracellular CNTF binding subunit (CNTFα) and two transmembrane signal transduction proteins: glycoprotein gp130 and LIF receptor. CNTF is considered as a potent survival factor of neurons and oligodendrocyteands may be relevant in reducing tissue destruction during inflammatory attacks. CNTF also is a survival factor for neurons of the peripheral sensory sympathetic and ciliary ganglia. It has been reported that CNTF could be an agent that has therapeutic potential and possibly induces differentiation of large multipolar ganglionic phenotype in a subset of progenitors.

生物活性

Measured in a cell proliferation assay using TF-1 cells. The ED50 for this effect is typically 74.4 ng/mL.

来源

重组表达

预测分子量

22.7 kDa

蛋白标签

No tag

SDS-PAGE

23.1 kDa, under reducing conditions; 23.3 kDa, under non-reducing conditions.

表达系统

E. coli Accession #: P20294 | E. coli

内毒素水平

<1.0 EU/μg

种属

大鼠(Rat)

氨基酸

2-200 aa

序列

AFAEQTPLTLHRRDLCSRSIWLARKIRSDLTALMESYVKHQGLNKNINLDSVDGVPVASTDRWSEMTEAERLQENLQAYRTFQGMLTKLLEDQRVHFTPTEGDFHQAIHTLMLQVSAFAYQLEELMVLLEQKIPENEADGMPATVGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRVISSHQMGISALESHYGAKDKQM

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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