Recombinant Human IL-21 Protein

重组人IL-21蛋白 | 重组人白细胞介素-21蛋白

CVID11 | IL21 | IL-21 | IL-21Za11interleukin-21 | interleukin 21 | interleukin-21 isoform | Za11

rp188212-10μg

10μg

无载体

≥90%(SDS-PAGE)

IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as a therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation).

Measured in a cell proliferation assay using mouse splenocytes. The ED50 for this effect is typically 27.01ng/mL

重组表达

15.3 kDa

No tag

16.5 kDa, under reducing conditions; 17.0 kDa, under non-reducing conditions.

E. coli Accession #: Q9HBE4 | E. coli

<1.0 EU/μg

人(Human)

32-162 aa

GQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS​

No

Yes