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Product details

名称

Recombinant Human CD3 gamma Protein

别名

重组人 CD3 gamma 蛋白 | 重组人CD3γ链蛋白

英文别名

CD3 gamma | CD3g antigen | gamma polypeptide (TiT3 complex) | CD3g molecule | epsilon (CD3-TCR complex) | gamma (CD3-TCR complex) | CD3g | CD3-GAMMA | FLJ17620 | FLJ17664 | FLJ79544 | FLJ94613 | IMD17 | MGC138597 | T3G | T-cell antigen receptor complex |

货号

rp188220-10μg

包装规格

10μg

级别

无动物源

浓度

≥90%(SDS-PAGE)

生化机理

T-cell surface glycoprotein CD3 gamma chain, also known as CD3G, is a 20 kDa single-pass type I membrane protein that is part of the TCR-CD3 complex. CD3 gamma forms a heterodimer with CD3 epsilon which associates with TCR beta, while CD3δ/CD3 epsilon heterodimer associates with TCR alpha. CD3 gamma /CD3 epsilon /TCR beta joins CD3δ/CD3 epsilon /TCR alpha and recruits a CD3 zeta homodimer to form the complete TCR-CD3 complex. CD3 chains contain one cytoplasmic ITAM domain which mediates intracellular signal transduction. The extracellular domain of CD3 gamma contains one disulfide bond and 2 N-linked glycosylation sites. The ECD of human CD3 gamma shares 60% and 62% sequence identity with mouse and rat CD3 gamma, respectively. The biologic roles of each CD3 chain and their relative contribution to the signals transduced through the TCR/CD3 complex and to downstream activation events are still uncertain, whether they may be specialized or redundant. Deficiencies in CD3 gamma can cause impairments in immune function, particularly in Treg cells which may contribute to autoimmune disorders. Post-translational: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8 (PubMed:2470098). Phosphorylated also by PKC; leading to the TCR complex down-regulation (PubMed:8187769).Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.

生物活性

Immobilized Recombinant Human CD3 gamma Protein (rp188220) at 1.0 μg/mL can bind Recombinant CD3G Antibody (Ab094727) with the EC50 of 8.0 ng/mL.

来源

重组表达

预测分子量

36.6 kDa

蛋白标签

C-hFc

SDS-PAGE

41.5-48.3 kDa, under reducing conditions; 84.9-101.2 & 175.7-211.0 kDa, under non-reducing conditions.

表达系统

HEK293 Accession #: P09693 | HEK293

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

1-116 aa

序列

MEQGKGLAVLILAIILLQGTLAQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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