Recombinant Human GABARAPL1 Protein

重组人GABARAPL1蛋白 | 重组人GABA A型受体相关蛋白样1蛋白

APG8 like | APG8L | ATG8 | ATG8B | ATG8L | Early estrogen regulated protein | Early estrogen-regulated protein | GABA | GABA(A) receptor associated protein like 1 | GABA(A) receptor-associated protein-like 1 | GABARAPL1 | GABARAPL1 a | Gamma aminobutyric

rp188255-10μg

10μg

无载体

≥95%(SDS-PAGE)

ATG8, also known as GABARAPL1, is a ubiquitin-like protein that has a crystal structure. ATG8 consists of a 5-stranded β-sheet, which is enclosed by two α-helices at one side and one α-helix at the other side and exhibits a conserved GABARAP domain. It functions in the formation of autophagosomal membranes. The transient conjugation of ATG8 to the autophagosomal membrane through a ubiquitin-like conjugation system is essential for autophagy in eukaryotes. Autophagy is induced upon nutrient depletion or rapamycin treatment and leads to the response of more than 30 autophagy-related (ATG) genes known so far, including ATG8. Post-translational: The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL1-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL1-II (By similarity). ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes. The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.

Immobilized Recombinant Human GABARAPL1 Protein (rp188255) at 3.0 μg/mL can bind GABARAPL1 Antibody (Ab104445) with the EC50 of 773.9 ng/mL.

重组表达

14.8 kDa

N-His

17.0 kDa, under reducing conditions; 17.4 kDa, under non-reducing conditions.

E. coli Accession #: Q9H0R8 | E. coli

<1.0 EU/μg

人(Human)

2-117 aa

MHHHHHHKFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEEDYFLYVAYSDESVYGK​

No

Yes