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Product details

名称

Recombinant Human PRAP1 Protein

别名

重组人PRAP1蛋白 | 重组人富含脯氨酸酸性蛋白1

英文别名

货号

rp188266-10μg

包装规格

10μg

级别

无动物源

浓度

≥90%(SDS-PAGE)

生化机理

PRAP1 is a protein interacting partner of MAD1 and that PRAP1 is able to down-regulate MAD1 and suppress mitotic checkpoint signalling in HCC. PRAP1 is a novel p53 target gene. The induction of PRAP1 expression by p53 may promote resistance of cancer cells to chemotherapeutic drugs such as 5-fluorouracil (5-FU), as knockdown of PRAP1 increases apoptosis in cancer cells after 5-FU treatment. PRAP1 appears to protect cells from apoptosis by inducing cell-cycle arrest, suggesting that the induction of PRAP1 expression by p53 in response to DNA-damaging agents contributes to cancer cell survival.

来源

重组表达

预测分子量

15.8 kDa

蛋白标签

C-His

SDS-PAGE

17.1 kDa, under reducing conditions; 17.1 kDa, under non-reducing conditions.

表达系统

HEK293 Accession #: Q96NZ9 | HEK293

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

1-151 aa (H101R)

序列

MRRLLLVTSLVVVLLWEAGAVPAPKVPIKMQVKHWPSEQDPEKAWGARVVEPPEKDDQLVVLFPVQKPKLLTTEEKPRGQGRGPILPGTKAWMETEDTLGRVLSPEPDHDSLYHPPPEEDQGEERPRLWVMPNHQVLLGPEEDQDHIYHPQHHHHHH

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

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