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名称

Recombinant Human Peroxiredoxin 1/PAG Protein

别名

重组人Peroxiredoxin 1/PAG蛋白 | 重组人过氧化还原酶1蛋白

英文别名

货号

rp188267-10μg

包装规格

10μg

级别

无载体

浓度

≥90%(SDS-PAGE)

生化机理

Peroxiredoxin-1, also known as Thioredoxin peroxidase 2, Natural killer cell-enhancing factor A, PRDX1, and PAGA, is a member of the ahpC/TSA family. Peroxiredoxin-1 is constitutively expressed in most human cells. It is induced to higher levels upon serum stimulation in untransformed and transformed cells. Peroxiredoxins (PRDXs) are a family of antioxidant enzymes that are also known as scavengers of peroxide in mammalian cells. The overexpression of Peroxiredoxin-1, which is one of the peroxiredoxins that is a ubiquitously expressed protein, was related to a poor prognosis in several types of human cancers. Peroxiredoxin-1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and may play an important role in eliminating peroxides generated during metabolism. Peroxiredoxin-1 Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. The reduced Peroxiredoxin-1 expression is an important factor in esophageal squamous cancer progression and could serve as a useful prognostic marker. Post-translational: Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.

生物活性

Immobilized Recombinant Human Peroxiredoxin 1/PAG Protein (rp188267) at 1.0 μg/mL can bind Recombinant Peroxiredoxin 1/PAG Antibody (Ab121313) with the EC50 of 3.6 ng/mL.

来源

重组表达

预测分子量

22.9 kDa

蛋白标签

N-His

SDS-PAGE

23.8 & 47.1 kDa, under reducing conditions; 23.0 & 25.7 & 42.9 kDa, under non-reducing conditions.

表达系统

E. coli Accession #: Q06830 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

2-199 aa

序列

MHHHHHHSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQKSKEYFSKQK

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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