Recombinant Human S100A1 Protein

重组人S100A1蛋白 | 重组人S100钙结合蛋白A1蛋白

protein S100-A1 | S100 alpha | S100 calcium binding protein A1 | S100 calcium-binding protein A1S100 | S-100 protein alpha chain | S-100 protein subunit alpha | S100 protein | alpha polypeptide | S100A | S100A1 | S100-alpha

rp188279-10μg

10μg

无载体

≥95%(SDS-PAGE)

S100A1 is a Ca2+ binding protein of the EF-hand type that belongs to the S100 protein family. S100 proteins consisting of at least 19 members exist as dimers in the cytoplasm and/or nucleus of a wide range of cells, and are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation. This protein has been shown to function in the processes including stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of PKC-mediated phosphorylation. Phosphoglucomutase is a target protein whose activity is antagonistically regulated by S100A1, and recently, S100A1 is also identified as a potent molecular chaperone and a new member of the Hsp70/Hsp90 multichaperone complex. S100A1 displays a tissue-specific expression pattern with highest levels in myocardium and is considered to be an important regulator of cardiac contractility. Accordingly, reduced expression or mutations of S100A1 gene have been implicated in cardiomyopathies. Post-translational: Glutathionylated; glutathionylation increases affinity to calcium about 10-fold.

Immobilized Recombinant Human S100A1 Protein (rp188279) at 5.0 μg/mL can bind Recombinant Human S100B Protein (rp188279) with a linear range of 0.0007-0.56 μg/mL.

重组表达

10.4 kDa

No tag

10.0 kDa, under reducing conditions; 10.0 & 20.9 kDa, under non-reducing conditions.

E. coli Accession #: P23297 | E. coli

<1.0 EU/μg

人(Human)

2-94 aa

GSELETAMETLINVFHAHSGKEGDKYKLSKKELKELLQTELSGFLDAQKDVDAVDKVMKELDENGDGEVDFQEYVVLVAALTVACNNFFWENS​

No

Yes