Recombinant Human CEACAM-21 Protein

重组人 CEACAM-21 蛋白 | 重组人癌胚抗原相关细胞粘附分子21蛋白

carcinoembryonic antigen-related cell adhesion molecule 21 | CEACAM21 | CEACAM-21 | CEACAM3 | FLJ13540 | MGC119874 | R29124_1

rp188290-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Carcinoembryonic antigen-related cell adhesion molecule-21 (CEACAM-21) is a member of the CEACAM subfamily of glycoproteins in the immunoglobulin (Ig) superfamily. The CEACAM-21 gene codes for both the CEACAM-3 and CEACAM-21 proteins and is located on chromosome 19. For CEACAM-21, the gene codes a 258 amino acid (aa) polypeptide consisting of a 206 aa extracellular domain (ECD), a 21 aa transmembrane domain, and a 32 aa cytoplasmic domain. The mature ECD contains a single IgV-like domain, common to all members of the CEACAM family, and one IgC2-like domain. CEACAM-21 is thought to be a primate-specific gene, and to date, no orthologs have been identified in lower species. Originally discovered as a biomarker for colorectal cancer, CEACAMs have now been associated with numerous intracellular signaling processes including cell adhesion, cell growth, recognition and differentiation, angiogenesis, and apoptosis. Although the specific function of the CEACAM-21 protein has yet to be elucidated, CEACAM-21 has been found to be overexpressed in heavy smokers and is associated with COPD susceptibility. It is also a candidate gene for schizophrenia in the Jewish population. CEACAM family members were identified as the major Galectin-3 receptor candidates on human neutrophils. Binding of carbohydrate ligands to CEACAMs may be important in the release of proinflammatory mediators.

Immobilized Recombinant Human Galectin-3 Protein (rp179829) at 2.0 μg/mL can bind Recombinant Human CEACAM-21 Protein (rp188290) with the EC50 of 1.22 μg/mL.

重组表达

24.0 kDa

C-His

30.7-38.3 kDa, under reducing conditions; 29.3-36.9 kDa, under non-reducing conditions.

HEK293 Accession #: Q3KPI0 | HEK293

<1.0 EU/μg

人(Human)

1-240 aa

MGPPSACPHRECIPWQGLLLTASLLTFWNAPTTAWLFIASAPFEVAEGENVHLSVVYLPENLYSYGWYKGKTVEPNQLIAAYVIDTHVRTPGPAYSGRETISPSGDLHFQNVTLEDTGYYNLQVTYRNSQIEQASHHLRVYESVAQPSIQASSTTVTEKGSVVLTCHTNNTGTSFQWIFNNQRLQVTKRMKLSWFNHVLTIDPIRQEDAGEYQCEVSNPVSSNRSDPLKLTVKSDDNTLGHHHHHH

Yes

Yes