Recombinant Human TCEB2/Elongin-B Protein

重组人TCEB2/Elongin-B蛋白 | 重组转录延伸因子B亚基2人蛋白 | 重组人延长素B蛋白

EloB | ELOB_HUMAN | Elongin 18 kDa subunit | Elongin B | Elongin-B | RNA polymerase II transcription factor SIII p18 subunit | RNA polymerase II transcription factor SIII subunit B | SIII | SIII p18 | TCEB 2 | Tceb2 | Transcription elongation factor B (SI

rp188312-10μg

10μg

无载体

≥95%(SDS-PAGE)

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

重组表达

13.9 kDa

N-His

15.8 kDa, under reducing conditions; 15.3 kDa, under non-reducing conditions.

E. coli Accession #: Q15370 | E. coli

<1.0 EU/μg

人(Human)

2-118 aa

MHHHHHHDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVQ

No

Yes