Recombinant Human ARF1 Protein

重组人ARF1蛋白 | 重组人ADP-核糖基化因子 1蛋白

ADP Ribosylation Factor 1 | ADP-ribosylation factor 1 | ARF 1 | ARF1 | ARF1_HUMAN

rp188332-10μg

10μg

无载体

≥90%(SDS-PAGE)

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. Post-translational: (Microbial infection) Demyristoylated by S.flexneri cysteine protease IpaJ which cleaves the peptide bond between N-myristoylated Gly-2 and Asn-3.

Immobilized Recombinant Human ARF1 Protein (rp188332) at 1.0 μg/mL can bind Recombinant ARF1 Antibody (Ab089466) with the EC50 of 4.8 ng/mL.

重组表达

21.5 kDa

N-His

18.0 kDa, under reducing conditions; 18.4 & 38.0 kDa, under non-reducing conditions.

E. coli Accession #: P84077 | E. coli

<1.0 EU/μg

人(Human)

2-181 aa

MHHHHHHGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQLRNQK

No

Yes