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Product details

名称

Recombinant Human CDKN2A/p16INK4a Protein

别名

重组人CDKN2A/p16INK4a蛋白

英文别名

货号

rp188347-10μg

包装规格

10μg

级别

无载体

浓度

≥95%(SDS-PAGE)

生化机理

CDKN2A germline mutations increase the risk of melanoma development. CDKN2A/CDK4 were the first high-penetrance melanoma genes identified. CDKN2A suppresses the initiation of melanoma invasion through inhibition of BRN2. It's a potential prognostic role of CDKN2A/B deletions in early disease stratification in pediatric B-ALL. CDKN2A coding region germline variants are associated with pancreatic adenocarcinoma (PC) susceptibility. Post-translational: Phosphorylation seems to increase interaction with CDK4.

生物活性

Immobilized Recombinant Human CDKN2A/p16INK4a Protein (rp188347) at 1.0 μg/mL can bind Recombinant CDKN2A/p16INK4a Antibody (Ab095843) with the EC50 of 7.2 ng/mL.

来源

重组表达

预测分子量

16.5 kDa

蛋白标签

No tag

SDS-PAGE

14.8 kDa, under reducing conditions; 14.8 & 33.4 kDa, under non-reducing conditions.

表达系统

E. coli Accession #: P42771 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

2-156 aa

序列

GEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSNHARIDAAEGPSDIPD

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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