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Product details
名称
Recombinant Human Cysteine Dioxygenase CDO1 Protein
别名
重组人Cysteine Dioxygenase CDO1蛋白
英文别名
CDO | CDO 1 | CDO I | CDO-I | Cdo1 | CDO1_HUMAN | CDOI | Cysteine dioxygenase type 1 | Cysteine dioxygenase type I | Cytosolic cysteine dioxygenase
货号
rp188349-10μg
包装规格
10μg
级别
无载体
浓度
≥90%(SDS-PAGE)
生化机理
CDO1(半胱氨酸二氧酶)是哺乳动物体内的一种非血红素铁酶,它能启动与丙酮酸和几种硫酸化合物(包括硫酸盐、低牛磺酸和牛磺酸)有关的许多重要代谢途径。CDO1 通过结合二氧催化 L-半胱氨酸向半胱氨酸亚硫酸(半胱氨酸亚硫酸盐)的转化。CDO1 是细胞半胱氨酸浓度的重要调节器,在维持肝脏细胞内游离半胱氨酸浓度在适当的狭窄范围内发挥着重要作用。CDO1 能够改变细胞内半胱氨酸水平和谷胱甘肽水平。CDO1 在肝脏和胎盘中高度表达。另一方面,CDO1 在心脏、大脑和胰腺中的表达量较低。在肝母细胞瘤 HepG2 细胞中也能检测到 CDO1。 翻译后:Cys-93 和 Tyr-157 之间的硫醚交联通过稳定 Fe2+ 离子发挥结构作用,并通过羟基氢抑制氧自由基,防止产生破坏性极强的自由羟基自由基。
来源
重组表达
预测分子量
23.8 kDa
蛋白标签
N-His
SDS-PAGE
22.2 kDa, under reducing conditions; 22.2 kDa, under non-reducing conditions.
表达系统
E. coli Accession #: Q16878 | E. coli
内毒素水平
<1.0 EU/μg
种属
人(Human)
氨基酸
2-200 aa
序列
MHHHHHHEQTEVLKPRTLADLIRILHQLFAGDEVNVEEVQAIMEAYESDPTEWAMYAKFDQYRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTNSHCFLKMLQGNLKETLFAWPDKKSNEMVKKSERVLRENQCAYINDSIGLHRVENISHTEPAVSLHLYSPPFDTCHAFDQRTGHKNKVTMTFHSKFGIRTPNATSGSLENN
无动物源
No
无载体
Yes
Safety
「No Dangerous Attributes」
Related
「No upstream and downstream information yet」
Technical Documents
「No technical documents」
Articles
「No related articles yet」
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Research chemical ≥90%

Research chemical ≥90%; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: ≥90%.

item number:rp188349-10μg
Product model:10μg
level: ≥90%
Lead Time:30days
sold 556 Items
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10μg

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