Recombinant Human Amylin/DAP Protein

重组人Amylin/DAP蛋白 | 重组人死亡相关蛋白1

Death-associated protein | DAP-1 | DAP | DAP1

rp188367-10μg

10μg

无载体

≥95%(SDS-PAGE)

Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation (By similarity). Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also acts as a negative regulator of autophagy (PubMed:20537536). Involved in mediating interferon-gamma-induced cell death (PubMed:7828849). Post-translational: Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy.

重组表达

11.9 kDa

N-His

15.4 kDa, under reducing conditions; 15.2 kDa, under non-reducing conditions.

E. coli Accession #: P51397 | E. coli

<1.0 EU/μg

人(Human)

2-102 aa

MHHHHHHSSPPEGKLETKAGHPPAVKAGGMRIVQKHPHTGDTKEEKDKDDQEWESPSPPKPTVFISGVIARGDKDFPPAAAQVAHQKPHASMDKHPSPRTQHIQQPRK

No

Yes