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Product details

名称

Recombinant Human DYNLL1/PIN Protein

别名

重组人DYNLL1/PIN蛋白 | 重组人动力蛋白轻链1蛋白

英文别名

货号

rp188378-10μg

包装规格

10μg

级别

无载体

浓度

≥95%(SDS-PAGE)

生化机理

Human Dynein Cytoplasmic Light Chain 1 (DYNLL1) has been identified as a protein that interacts with NOS1, leading to NOS1 inhibition. NOS1 dimer is destabilized after binding DYNLL1 a conformation necessary activity, and it regulate numerous biologic processes throughits effects on nitric oxide synthase activity. DYNLL1 is widely expressed, with higher expression in testis and moderate expression in brain. Post-translational: Phosphorylation at Ser-88 promotes recruitment to DNA double-strand breaks (DSBs) by TP53BP1 and ability to inhibit MRE11 (PubMed:37696958). Phosphorylation at Ser-88 appears to control the dimer-monomer transition (PubMed:15193260, PubMed:18650427). According to PubMed:15193260, it is phosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro (PubMed:15193260, PubMed:18650427).

生物活性

Immobilized Recombinant Human DYNLL1/PIN Protein (rp188378) at 1.0 μg/mL can bind Recombinant DYNLL1/PIN Antibody (Ab100668) with the EC50 of 4.9 ng/mL.

来源

重组表达

预测分子量

11.2 kDa

蛋白标签

N-His

SDS-PAGE

11.2 kDa, under reducing conditions; 11.2 kDa, under non-reducing conditions.

表达系统

E. coli Accession #: P63167 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

2-89 aa

序列

MHHHHHHCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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