Recombinant Human ETHE1 Protein

重组人ETHE1蛋白 | 重组人线粒体过硫化物双加氧酶ETHE1

Ethe1 | ETHE1 protein, mitochondrial precursor | ETHE1_HUMAN | ethylmalonic encephalopathy 1 | Ethylmalonic encephalopathy protein 1 | hepatoma subtracted clone one | Hepatoma subtracted clone one protein | HSCO | mitochondrial | Protein ETHE1 | Protein E

rp188388-10μg

10μg

无载体

≥90%(SDS-PAGE)

Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H2S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H2S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (PubMed:12398897).

重组表达

27.5 kDa

N-His

26.7 kDa, under reducing conditions; 26.7 kDa, under non-reducing conditions.

E. coli Accession #: O95571 | E. coli

<1.0 EU/μg

人(Human)

13-254 aa

MHHHHHHLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAVNTHCHADHITGSGLLRSLLPGCQSVISRLSGAQADLHIEDGDSIRFGRFALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTLPGDCLIYPAHDYHGFTVSTVEEERTLNPRLTLSCEEFVKIMGNLNLPKPQQIDFAVPANMRCGVQTPTA

No

Yes