Recombinant Human DNAJB2 Protein

重组人DNAJB2蛋白 | 重组人DnaJ热休克蛋白家族 (Hsp40) 成员B2蛋白

Descriptions | DnaJ (Hsp40) homolog subfamily B member 2 | DnaJ homolog subfamily B member 2 | DnaJ protein homolog 1 | DNAJB2 | Heat shock 40 kDa protein 3 | Heat shock protein J1 | Heat shock protein neuronal DNAJ like 1 | HSJ 1 | HSJ1 | HSPF3

rp189393-10μg

10μg

无载体

≥85%(SDS-PAGE)

Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:22219199, PubMed:7957263). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278). Post-translational: Ubiquitinated by STUB1; does not lead to proteasomal degradation.

重组表达

31.4 kDa

N-His

33.2 kDa, under reducing conditions; 33.6 kDa, under non-reducing conditions.

E. coli Accession #: P25686-2 | E. coli

<1.0 EU/μg

人(Human)

2-277 aa

MHHHHHHASYYEILDVPRSASADDIKKAYRRKALQWHPDKNPDNKEFAEKKFKEVAEAYEVLSDKHKREIYDRYGREGLTGTGTGPSRAEAGSGGPGFTFTFRSPEEVFREFFGSGDPFAELFDDLGPFSELQNRGSRHSGPFFTFSSSFPGHSDFSSSSFSFSPGAGAFRSVSTSTTFVQGRRITTRRIMENGQERVEVEEDGQLKSVTINGVPDDLALGLELSRREQQPSVTSRSGGTQVQQTPASCPLDSDLSEDEDLQLAMAYSLSEMEAAGKKPADVF

No

Yes