Recombinant Human Lipin 1/LPIN1 Protein

重组人Lipin 1/LPIN1蛋白 | 重组人立平1蛋白

LPIN1 | PAP1

rp189493-10μg

10μg

无载体

≥90%(SDS-PAGE)

Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels (PubMed:20231281, PubMed:23426360, PubMed:29765047, PubMed:31695197). Is involved in adipocyte differentiation (By similarity). Recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity). Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression (By similarity). Post-translational: Phosphorylated at multiple sites by mTOR in response to insulin, leading to its inactivation (PubMed:23426360). Phosphorylation does not affect the catalytic activity but regulates the localization (By similarity). Phosphorylation is decreased by epinephrine (By similarity). Dephosphorylated by the CTDNEP1-CNEP1R1 complex (By similarity). Dephosphorylation following mTOR inhibition promotes its activity (PubMed:31695197). Acetylation at Lys-425 and Lys-595 by KAT5 in response to fatty acids promotes translocation to the endoplasmic reticulum and synthesis of diacylglycerol. Sumoylated.

重组表达

21.1 kDa

N-His

21.1 kDa, under reducing conditions; 44.4 kDa, under non-reducing conditions.

E. coli Accession #: Q14693 | E. coli

<1.0 EU/μg

人(Human)

301-460 aa

MHHHHHHICDKSHFQAIHSESSDTFSDQSPTLVGGALLDQNKPQTEMQFVNEEDLETLGAAAPLLPMIEELKPPSASVVQTANKTDSPSRKRDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDPSGLAKHASDNGARSANQSPQSVGSSGVDSGVESTSDGLRD

No

Yes