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Product details

名称

Recombinant Human Endothelin-2/ET-2 Protein

别名

重组人Endothelin-2蛋白 | 重组人ET-2蛋白 | 重组人内皮素-2蛋白

英文别名

货号

rp192066-10μg

包装规格

10μg

级别

无载体

浓度

≥90%(SDS-PAGE)

生化机理

Endothelin-2 is a Hypoxia-induced Autocrine Survival Factor for Breast Tumor Cells. The synthesis of EDN2 by human kidney carcinoma cells is decreased by EGF. EDN2 is a chemoattractant for macrophages and THP-1 monocytic cells. Chemotaxis towards EDN2 is via the MAPK pathway: p44 and p42 are phosphorylated when THP-1 cells are stimulated with EDN2. Migration to EDN2 is inhibited by hypoxia and by pertussis toxin. EDN2 leads to activation of macrophages. EDN2 shares a similar peptide sequence with chemokines and may signal via a similar receptor and MAPK-mediated pathway. Furthermore, EDN2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia.

来源

重组表达

预测分子量

18.4 kDa

蛋白标签

N-His

SDS-PAGE

18.3 & 35.7 kDa, under reducing conditions; 21.3 & 35.3 & 51.6 kDa, under non-reducing conditions.

表达系统

E. coli Accession #: P20800 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

25-178 aa

序列

MHHHHHHQAAATLEQPASSSHAQGTHLRLRRCSCSSWLDKECVYFCHLDIIWVNTPEQTAPYGLGNPPRRRRRSLPRRCQCSSARDPACATFCLRRPWTEAGAVPSRKSPADVFQTGKTGATTGELLQRLRDISTVKSLFAKRQQEAMREPRSTHSRWRKR

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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