Recombinant Human GPR37 Protein

重组人GPR37蛋白 | 重组人前酵素受体GPR37蛋白

EDNRBL | Endothelin B receptor-like protein 1 | ETBR-LP-1 | G protein-coupled receptor 37 (endothelin receptor type B-like) | GPR37 | hET(B)R-LP | PAELR | PAELRETBR-LP-1 | Parkin-associated endothelin receptor-like receptor | probable G-protein coupled re

rp192118-10μg

10μg

无动物源

≥95%(SDS-PAGE)

GPR37 (G-protein coupled receptor 37), also called ETBR-LP-1 (endothelin B receptor-like protein 1) or PAELR (Parkin-associated endothelin receptor-like receptor), is a 587 aa, 7-transmembrane receptor for the neuroprotective and glioprotective factor prosaposin. It is mainly expressed in neuronal cells, particularly in cerebellar Purkinje cells and the hippocampus. It is a substrate of the E3 ubiquitin ligase, parkin, which is up-regulated during endoplasmic reticulum stress. In a juvenile form of Parkinson's disease, GPR37 accumulates, contributing to stress-induced neuronal cell death. The extracellular domains (aa 27-265) of human and mouse GPR37 share 68% aa identity. Post-translational: The N-terminus is cleaved by ADAM10 metalloproteinase; mediating limited proteolysis leading to the release of receptor ectodomain by shedding (PubMed:26869225, PubMed:34042202).In addition, cleaved by FURIN between Arg-54 and Asp-55 (PubMed:34042202). Ubiquitinated by PRKN in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.

Immobilized Recombinant Human GPR37 Protein (rp192118) at 1.0 μg/mL can bind Recombinant GPCR/GPR37 Antibody (Ab106130) with the EC50 of 2.9 ng/mL.

重组表达

29.3 kDa

C-10His

31.3-53.3 kDa, under reducing conditions; 31.3-53.3 kDa, under non-reducing conditions.

HEK293 Accession #: O15354 | HEK293

<1.0 EU/μg

人(Human)

1-265 aa

MRAPGALLARMSRLLLLLLLKVSASSALGVAPASRNETCLGESCAPTVIQRRGRDAWGPGNSARDVLRARAPREEQGAAFLAGPSWDLPAAPGRDPAAGRGAEASAAGPPGPPTRPPGPWRWKGARGQEPSETLGRGNPTALQLFLQISEEEEKGPRGAGISGRSQEQSVKTVPGASDLFYWPRRAGKLQGSHHKPLSKTANGLAGHEGWTIALPGRALAQNGSLGEGIHEPGGPRRGNSTNRRVRLKNPFYPLTQESYGAYAVMHHHHHHHHHH

Yes

Yes