Recombinant Human IL36 beta/IL-1F8 Protein

重组人IL36 beta/IL-1F8蛋白 | 重组人IL36 beta蛋白 | 重组人白细胞介素36 beta蛋白

family of interleukin 1-eta | FIL1 eta | FIL1 | FIL1-(ETA) | FIL1H | FILI-(ETA) | IL-1 eta | IL1-ETA | IL1F8 (Canonical product IL-1F8a) | IL-1F8 (FIL1-eta) | IL1F8 | IL-1F8 | IL1H2 | IL-1H2 | IL36 beta | IL-36 beta | IL36B | interleukin 1 family | interl

rp192262-10μg

10μg

无载体

≥95%(SDS-PAGE)

Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contain a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines includes four members, with three having pro-inflammatory effects such as IL1F8 and the fourth member being an IL-1 receptor antagonist (IL-1Ra). IL-1 family members exert their effects through binding to receptors that belong to the IL-1 receptor (IL-1R) family. IL1F8 exerts proinflammatory effects in primary human joint cells. Joint and serum IL-1F8 protein levels did not correlate with inflammation, but they were high in some human serum samples tested, including samples from patients with rheumatoid arthritis. IL1F8 also activated NK-κB. Post-translational: N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).

Testing in progress

重组表达

30.9 kDa

C-His & Sumo

32.5 kDa, under reducing conditions; 32.5 kDa, under non-reducing conditions.

E. coli Accession #: Q9NZH7 | E. coli

<1.0 EU/μg

人(Human)

5-157 aa

MGSSHHHHHHSSGLVPRGSHMASMSDSEVNQEAKPEVKPEVKPETHINLKVSDGSSEIFFKIKKTTPLRRLMEAFAKRQGKEMDSLRFLYDGIRIQADQTPEDLDMEDNDIIEAHREQIGGREAAPKSYAIRDSRQMVWVLSGNSLIAAPLSRSIKPVTLHLIACRDTEFSDKEKGNMVYLGIKGKDLCLFCAEIQGKPTLQLKEKNIMDLYVEKKAQKPFLFFHNKEGSTSVFQSVSYPGWFIATSTTSGQPIFLTKERGITNNTNFYLDSVE​

No

Yes