重组人源化XVII型胶原蛋白

重组人XVII型胶原蛋白

COL17A1 | ERED | JEB4 | BP180 | BPA-2 | BPAG2 | LAD-1 | BA16H23.2 | Collagen XVII | Collagen 17

rp212899-1mg

1mg

无动物源

≥95%(SDS-PAGE)

XVII型胶原蛋白（XVII collagen，COL17）是表皮基底层的一种跨膜蛋白，具有维持表皮真皮之间的紧密连接，以促进表皮更替、稳固基底膜的功能,从基底膜带上实现抗衰修复。已有证据表明，COL17水解可引起毛囊微型化最终导致脱发。COL17因其特有的生理功能，在延缓治疗脱发有很好的应用前景。 本产品是重组的人源化XVII型胶原蛋白，来源于微生物。该产品具有优异的水溶性和稳定性，并具有很好的亲水性和保湿性。采用毕赤酵母菌发酵工艺，确保产品内毒素更低、更安全。 产品特性： PH: 5-8 电泳纯度：≥95% (SDS-PAGE) 蛋白含量：>90% 干燥失重： Type XVII collagen (COL17) is a transmembrane protein in the basal layer of epidermis, which has the functions of maintaining close connection between epidermis and dermis, promoting epidermis replacement and stabilizing basement membrane, and realizing anti-aging repair from basement membrane belt. It has been proved that hydrolysis of COL17 can cause hair follicle miniaturization and eventually lead to hair loss. COL17 has a good application prospect in delaying the treatment of alopecia because of its unique physiological function. This product is a recombinant humanized XVII collagen, which comes from microorganisms. The product has excellent water solubility and stability, and has good hydrophilicity and moisture retention. Pichia pastoris fermentation process is adopted to ensure that the endotoxin of the product is lower and safer. Product Features: PH: 5-8 Electrophoretic purity: ≥95% (SDS-PAGE) Protein content : >90% Loss on drying:

May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. Post-translational: The intracellular/endo domain is disulfide-linked. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. The ectodomain is shedded from the surface of keratinocytes resulting in a 120-kDa soluble form, also named as 120 kDa linear IgA disease antigen. The shedding is mediated by membrane-bound metalloproteases. This cleavage is inhibited by phosphorylation at Ser-544.

重组表达

10 kDa

His

10-15 kDa

62168000

毕赤酵母 Accession #: Q9UMD9 | 毕赤酵母

<5.0 EU/mg

人(Human)

Yes

Yes