Recombinant Human Cytochrome c Protein

重组人CYCS蛋白 | 重组人细胞色素c蛋白

CYC | CYC_HUMAN | CYCS | Cytochrome c | Cytochrome c somatic | HCS | THC4

rp214398-10μg

10μg

无载体

≥95%(SDS-PAGE)

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. Post-translational: Binds 1 heme c group covalently per subunit. Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.

重组表达

12.6 kDa

C-His

14.0 & 27.3 kDa, under reducing conditions; 14.0 & 27.3 kDa, under non-reducing conditions.

E. coli Accession #: P99999 | E. coli

<1.0 EU/μg

人(Human)

1-105 aa

MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGYSYTAANKNKGIIWGEDTLMEYLENPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNEHHHHHH

No

Yes