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Product details

名称

Recombinant Human p63 Protein

别名

重组人p63蛋白 | 重组人肿瘤蛋白63

英文别名

AIS | Amplified in squamous cell carcinoma | B(p51A) | B(p51B) | Chronic ulcerative stomatitis protein | CUSP | DN p63 alpha 1 | DNp63 | EEC3 | id:ibd3516 | Keratinocyte transcription factor | Keratinocyte transcription factor KET | KET | LMS | MGC115972

货号

rp214418-10μg

包装规格

10μg

级别

无载体

浓度

≥90%(SDS-PAGE)

生化机理

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Post-translational: May be sumoylated. Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.

来源

重组表达

预测分子量

35.0 kDa

蛋白标签

N-His

SDS-PAGE

31.8 kDa, under reducing conditions; 31.1 & 76.2 & 131.9 kDa, under non-reducing conditions.

表达系统

E. coli Accession #: Q9H3D4 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

381-680 aa

序列

MHHHHHHNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHEFSSPSHLLRTPSSASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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