Recombinant Human Pax6 Protein

重组人Pax6蛋白 | 重组人成对框蛋白Pax-6

AN | AN 2 | AN2 | Aniridia type II protein | D11S812E | FVH1 | KIAA0552 | Leucine zipper putative tumor suppressor 3 | LZTS3 | MGC17209 | MGDA | Oculorhombin | Paired box 6 | Paired Box Gene 6 | Paired box gene 6 (aniridia keratitis) | Paired box homeotic

rp214452-10μg

10μg

无载体

≥90%(SDS-PAGE)

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes. Post-translational: Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation.

重组表达

47.5 kDa

N-His

46.7 & 100.8 & 120.8 kDa, under reducing conditions; 45.3 & 97.3 & 117.8 kDa, under non-reducing conditions.

E. coli Accession #: P26367 | E. coli

<1.0 EU/μg

人(Human)

2-422 aa

MHHHHHHQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ

No

Yes